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Laboratory of Plant and Process Design Emil-Figge-Str. 70 Geschossbau 2 44227 Dortmund Germany
Room G2-R3.20
Fatma van Winssen studied Biochemical Engineering at the Technische Universität Dortmund. She finished her studies in March 2010 with her diploma thesis "Development of a guideline for knowledge-based syntheses of downstream processes of proteins and peptides". Since Mai 2010 she is employed at the Laboratory of Plant and Process Design. Her research focuses on aqueous two-phase extraction of enzymes.
Aqueous Two Phase Extraction, (ATPE) represents a promising alternative unit operation for downstream processing of biotechnological products. The used systems consist of aqueous solutions of two polymers or one polymer and one salt. They provide several advantages such as a biocompatible environment enabling for gentle extraction conditions. However, long phase separation times of the emulsions are limiting ATPE.
In this work we investigate a novel technology to overcome the long phase separation times. In the so called Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®) - Technology porous particles are impregnated with an aqueous polymer phase and suspended in the second aqueous phase. Thus, phase contact is achieved via the suspension of the impregnated particles and phase emulsification and separation of the classical ATPE setup are unnecessary. Aim of this work is the investigation of the TAPPIR® - Technology for downstream processing of proteins
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