Telephone (+49)231 755-2339
Fax (+49)231 755-2341
Laboratory of Plant and Process Design Emil-Figge-Str. 70 Geschossbau 2 44227 Dortmund Germany
Room G2-R3.20
Maria-Sibylla-Merian-Gymnasium,Krefeld (Germany)
Biochemical Engineering Studies, TU Dortmund University,Diploma thesis: Conception of a capillary reactor in micro-/milli-scale concerning the process- and equipment-design for three-phase-systems (liquid-liquid-solid) and the computational research on the formation of the characteristic liquid-liquid slug flow using CFD-Simulation
Field of research: Experimental-based development of downstream processes for biotechnological products for a systematic process design
The manufacturing costs of biotechnological products accounts for a great amount of the purification steps during downstream processing. In order to reduce such costs, the Laboratory of Process and Plant Design works on different concepts for systematic development of downstream processes.
In this thesis the experimental-based approach for process synthesis is the focus of research. For a systematic development the use of experimental-based indicator-functions (so-called Key Performance Indicators, KPI) has proven successful to rate different purification steps technically and economically. Those indicators will be implemented into a systematic methodology to be used as optimizing parameter in experimental investigations. In order to generate reliable and reproducible experimental data, a semi-automated robotic platform is used (Zinsser Analytic). In this way, the KPIs in combination with robot-aided, automated experiments as well as the use of Design of Experiment (DoE)-approaches results in a comprehensive tool for systematic development of downstream processes.
For method development and evaluation the purification of biotechnological products is applied, for example the purification of rebaudioside A from the leaves of Stevia Rebaudiana.
Papers
