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Stefan Heisel

Stefan Heisel Photo of Stefan Heisel

Telephone
(+49)231 755-2339

Fax
(+49)231 755-2341

Address

Room G2-R3.20

Contents

 

Curriculum Vitae:

Born

19.07. in Herne (Germany)

1999-2008 Adalbert-Stifter-Gymnasium, Castrop-Rauxel (Germany)
2009-2013

B.Sc. Biochemical Engineering Studies, TU Dortmund University

Bachelor thesis: Development of an Image Analysis Tool to Determine the Agglomeration Degree of Crystalline Products

2012 Semester abroad at Hong Kong University of Science and Technology (Hong Kong)
2013-2015

M.Sc. Biochemical Engineering Studies, TU Dortmund University

Master thesis: Formation of Pharmaceutical Cocrystals from Solvent Mixtures

Since 2016

PhD at the Laboratory of Plant and Process Design, TU Dortmund University

Field of research: Investigation of agglomeration processes during organic compound crystallization

 

Field of Research

Crystallization is a common technique for separation, purification as well as product design of organic compounds. Due to the increasing demand in specific product characteristics, optimization of the crystallization process is of high interest. Crystalline products are widely characterized by the crystal size distribution (CSD); however, no information is given about the agglomeration –the bonding of single crystals by solid bridges - of the crystals.

In this work, the focus is on the agglomeration processes occurring during crystallization. For this matter, a new experimental setup is developed that uses image analysis to make high quality videos of the crystal suspension. Image analysis and sophisticated classification tools that were already developed in the past (Terdenge et al., 2015), are used to distinguish between the different types of crystals. The aim is gain a more detailed understanding of the agglomeration processes and to use this knowledge for optimization of the crystallization process.


Publications

    Papers

    • S. Heisel, J. Holtkötter, K. Wohlgemuth
      Measurement of agglomeration during crystallization: Is thedifferentiation of aggregates and agglomerates via ultrasonic irradiation possible?
      Chemical Engineering Science 210 (2019) 115214

    • S. Heisel, J. Ernst, A. Emshoff, G. Schembecker, K. Wohlgemuth
      Shape-independent particle classification for discrimination of single crystals and agglomerates
      Powder Technology 345 (2019) 425-437

    • S. Heisel, M. Rolfes, K. Wohlgemuth
      Discrimination between Single Crystals and Agglomerates during the Crystallization Process
      Chemical Engineering & Technology 41 (6) (2018) 1218-1225

     

    • S. Heisel; T. Kovačević; H. Briesen, G.Schembecker, K. Wohlgemuth
      Variable Selection and Training Set Design for Particle Classification using a Linear and a Non-Linear Classifier
      Chemical Engineering Science 173 (2017) 131-144

    • L.-M. Terdenge, S. Heisel, G. Schembecker, K. Wohlgemuth
      Agglomeration degree distribution as quality criterion to evaluate crystalline products
      Chemical Engineering Science 133 (2015) 157-169

    Conference Proceedings

     

    • S. Heisel , M. Rolfes, K. Wohlgemuth
      Image-based discrimination of single crystals and agglomerates during batch cooling crystallization
      Proceedings of the 25th International Workshop on Industrial Crystallization “BIWIC” (2018) 195-200
       
    • S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
      Evolution of the agglomeration degree over time during batch cooling crystallization
      Proceedings of the 24th International Workshop on Industrial Crystallization “BIWIC” (2017) 60-65
      Verlag Dr. Hut, ISBN 978-3-8439-3247-9

    Oral presentations

    • S. Heisel, M. Rolfes, K. Wohlgemuth
      Differentiation of adipic acid aggregates and agglomerates during batch cooling crystallization
      Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Bremen, DEU (2018)

    • S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
      Evolution of the agglomeration degree over time during batch cooling crystallization
      24th International Workshop on Industrial Crystallization “BIWIC”, Dortmund, DEU (2017)
    • S. Heisel, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
      Online Investigation of Agglomeration Processes during Batch Cooling Crystallization
      Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Köln, DEU (2017)


    Poster presentations

    • S. Heisel, M. Rolfes, K. Wohlgemuth
      Image-based discrimination of single crystals and agglomerates during batch cooling crystallization: Necessity of disaggregation for accurate measurement
      25th International Workshop on Industrial Crystallization “BIWIC”, Rouen, FRA (2018)

    • S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
      Online measurement of the agglomeration degree of adipic acid during batch cooling crystallization
      20th International Symposium on Industrial Crystallization “ISIC”, Dublin, IRL (2017)